As is customary in the pharmaceutical industry, we use CROs to conduct and support our preclinical studies and clinical trials under our close supervision and overall management.
Summary · 第 14 页
We have adopted procedures to ensure that production qualifications, facilities and processes of CMOs/CDMOs comply with the relevant regulatory requirements and our internal guidelines.
Business · 第 309 页
To ensure the production process consistency, we will collaborate with reputable CMOs/CDMOs to manufacture certain drug candidates for pivotal clinical trials, followed by initial commercialization.
We outsource and subcontract the manufacturing of our products to multiple contract manufacturers located in China. We believe that outsourcing the manufacturing of our products enables greater scale and flexibility at lower costs than establishing our own manufacturing facilities.
Business · 第 187 页
Although we generally do not restrict our outsourcing and subcontracting partners to supply fitness products to other parties, they are required to supply exclusively to us the fitness products that are protected under our intellectual properties, such as smart fitness devices and certain fitness gear collections.
Business · 第 187 页
Although we do not have employees stationed at the facilities of our outsourcing and subcontracting partners, our quality control team performs sampling inspection to ensure that our outsourcing and subcontracting partners fully adhere to our quality standards.
巨星传奇集团有限公司Star Plus Legend Holdings Limited06683.HK
产品生产全部外包予第三方制造商
Our products are manufactured by selected third-party manufacturers in China that specialize in the manufacturing of skincare products or nutritional food.
Business · 第 249 页
We from time to time enter into OEM cooperation framework agreements with OEM manufacturers in relation to the production of various products.
Business · 第 254 页
We are entitled to check and inspect Hangzhou Hengmei’s factories and quality control system.
众安智慧生活服务有限公司Zhong An Intelligent Living Service Limited02271.HK
将清洁绿化维修等劳务外包予分包商
In 2020, 2021 and 2022, subcontracting costs amounted to RMB14.2 million, RMB20.7 million and RMB20.1 million, respectively, which accounted for approximately 9.9%, 11.2% and 9.9%, respectively, of our total cost of sales.
Business · 第 277 页
To ensure the overall quality of our subcontractors, we maintain a list of subcontractors based on our series of assessment standards, including, among others, the amount of registered capital, qualifications, size of overall operations, track record performance, management style and operational procedures.
Business · 第 278 页
We also conduct annual surveys among property owners and residents regarding the quality of services provided by our subcontractors.
We currently outsource certain manufacturing activities, primarily the production of small molecules, to industry-recognized CMOs in China, and we intend to continue doing so in the future.
Business · 第 382 页
To monitor and evaluate the services of our CMOs, we conduct quality assurance audit programs to ensure, among other criteria, full compliance of our CMOs with the relevant regulatory requirements.
Business · 第 382 页
In addition to conducting our core R&D activities in-house, we also engage reputable CROs to manage, conduct, and support our preclinical research and clinical trials.
For the years ended 31 December 2020, 2021 and 2022, we engaged 37, 26 and 18 contractors in the PRC who were engaged in engineering and construction business for the construction of heat service facilities such as primary distribution pipelines and heat exchange stations, respectively.
Business · 第 272 页
We would engage qualified external contractors for carrying out the construction. The qualified external contractors engaged by us would be responsible for constructing the facilities as well as installing and testing the relevant equipment, instruments and systems.
Business · 第 227 页
It is our Group's policy to select our contractors for the construction of pipelines and heat service facilities through competitive tender process or competitive negotiation.
We collaborate with our CDMO partners (including both CMOs and CDMOs) to manufacture a portion of our drug candidates to supply for pre-clinical studies, clinical trials and potentially for the commercial-scale production of large molecule drugs.
Business · 第 325 页
In 2021 and 2022, the expenses related to CDMO partners included in our research and development expenses were RMB42.6 million and RMB98.3 million, respectively.
Business · 第 327 页
LAE002, the drug candidate that we expect to first commercialize, will be initially manufactured by CDMOs upon marketing approval and later transferred to our own manufacturing facility upon approval by competent regulatory authority.
For other product dosage forms that cannot be produced at this stage in our Wuxi plant, we engage CDMO for shared production facilities, reduced investment in fixed assets, and reduced R&D and conversion time.
Business · 第 321 页
In terms of the involvement and contributions of each of the major CDMO partners (including CMOs) to the development of our product candidates, we collaborate with our CDMO partners to manufacture a portion of our product candidates to supply for pre-clinical studies and clinical trials.
Business · 第 324 页
We maintained cooperation relationship with 27 and 39 CRO and CDMO partners in 2021 and 2022, respectively.
To balance efficiency, service quality and scalability, and in order to satisfy our customers' nationwide, diverse and complete technical support demand, we also collaborate with third-party technical companies for their engineers to support our managed IT services in geographical areas where we have less presence.
宏信建设发展有限公司Horizon Construction Development Limited09930.HK
工程及技术服务依赖分包商提供劳动力
In order to maintain a flexible workforce, and considering our diversified services portfolio and the needs to expand our engineering and technical services segment, we will need to rely on subcontractors to provide an external labor force to provide engineering and technical services to our customers.
Business · 第 201 页
Starting from the year ended December 31, 2019, we made adjustments to our engineering and technical services portfolio so that we would offer more services for labor-intensive on-site construction work, on which we will require the procurement of a subcontracted labor force.
Business · 第 201 页
Whilst we are also in the process of gradually building up in-house engineering and technical services team, our Directors estimate that we will continue to rely on subcontractors to provide a certain level of workforce for this business segment in the future.
We enter into service agreements with labour service suppliers, who engage marketers as their employees or contractors.
Business · 第 238 页
With a view to mitigating our risks exposures, we have established control measures to assess risks and determine whether to purchase insurances, such as third-party liability insurance, exhibition insurance, accident insurance, etc., for different projects having considered different customers' requirements and would generally require our labour service suppliers (i.e. suppliers which provide us with third-party marketers) to purchase such insurances.
During the Track Record Period, our major suppliers primarily consisted of (i) suppliers of raw materials and consumables for our vaccine and therapeutic biologics development, (ii) construction service providers, (iii) property leasing providers and (iv) CROs, who provide third-party contracting services for research and development.
Business · 第 314 页
During the Track Record Period, we engaged 18 CROs and one SMO based on the needs of our pre-clinical and clinical studies.
Business · 第 316 页
Our procurement of CRO and SMO services will continue to depend on the cadence of our clinical and pre-clinical studies.
怡俊集团控股有限公司Easy Smart Group Holdings Limited02442.HK
劳动密集工序全部分包予分包商
We engage subcontractors to perform more labour intensive works such as the installation and application of the passive fire protection materials and components to enable us to control our staff costs and focus on the most crucial aspects of a passive fire protection works project
Business · 第 165 页
Despite such delegation, we maintain control over our subcontractors and monitor the quality of the services provided.
Business · 第 165 页
For the years ended 30 June 2020, 2021 and 2022 and the four months ended 31 October 2022, we incurred subcontracting fees of approximately HK$55.5 million, HK$59.7 million, HK$95.5 million and HK$52.3 million, respectively.
Additionally, we also work with selected third-party distilleries which produce base liquor for us strictly in accordance with our specifications and requirements.
Financial Information · 第 266 页
These collaborated distilleries provided us with approximately 7,404 tons, 20,546 tons and 7,817 tons of sauce aroma base liquor in 2020, 2021 and 2022, respectively.
Financial Information · 第 266 页
As we continue to build additional production facilities to enhance our production capacity, we expect to gradually reduce sourcing base liquor from these collaborated distilleries.
Our suppliers during the Track Record Period were mainly providers for services including server, research and development, cloud computing, storage capacity and telecommunications.
Business · 第 245 页
During the Track Record Period, we engaged third-party research and development service providers mainly for the upgrade of our CRM system, as well as the development of certain module components of our Powershopy platform.
Business · 第 245 页
We select suppliers based on a variety of factors, including their qualification, reputation, pricing and overall services.
中天建设（湖南）集团有限公司Zhongtian Construction (Hunan) Group Limited02433.HK
劳务及专业施工分包占销售成本约35%至41%
For each of FY2019, FY2020, FY2021 and 3Q2022, the total labour and construction subcontracting fees paid by us to the subcontractors engaged by us amounted to approximately RMB569.0 million, RMB569.6 million, RMB644.4 million and RMB502.1 million, respectively, accounting for approximately 34.7%, 36.0%, 39.6% and 41.2% of our total cost of sales, respectively.
Business · 第 277 页
We follow strict criteria in selecting subcontractors and maintain a list of qualified subcontractors which we would usually choose from.
Business · 第 277 页
In the event of any material failure by our subcontractors to meet our safety or quality standards, we may cease to work with and/or claim damages from them.
洲际船务集团控股有限公司Seacon Shipping Group Holdings Limited02409.HK
船员配备服务外包且曾依赖关连方
During the years ended December 31, 2019, 2020 and 2021 and the nine months ended September 30, 2022, the transaction costs of the crew manning services procured from Haizhou Crew Manning (Qingdao) and Sinostar Crew Manning Co., Ltd amounted to approximately USD11.5 million, USD19.3 million, USD25.8 million and USD14.2 million, respectively, representing approximately 45.8%, 57.8%, 53.9% and 34.8% of our total crew manning expenses for the corresponding periods.
Business · 第 268 页
Our Directors consider that outsourcing crew manning to our related parties Haizhou Crew Manning (Qingdao) and Sinostar Crew Manning during the Track Record Period is in our commercial interests as our related parties are able to provide the necessary crewing services that suit our needs most appropriately at service fees not higher than service fees we pay Independent Third Parties in comparable transactions.
Business · 第 268 页
Completion of the transfer of shares in Haizhou Crew Manning (Qingdao) took place on October 27, 2022, and the transfer of shares in Sinostar Crew Manning took place on November 14, 2022.